Smart hydrogels with the ability to respond to a change in the surrounding environment have gained significant interest in recent years. For biomedical applications, gels that respond to differences in pH in the physiological range are of particular interest. In this study we report on the synthesis and characterization of pH-responsive double hydrophilic triblock-copolymers of ABA type. Using photoinitiated thiol-ene chemistry poly[allyl glycidyl ether)-b-(ethylene oxide)-b-(allyl glycidyl ether)] (PAGE-PEO-PAGE) polymers were functionalized with pH-responsive imidazole moieties. The pH-responsive and gelforming properties at physiological pH were characterized and the viscoelastic and morphological properties of the gels were investigated.

Novel reversible hydrogels with pH-responsiveness at physiological pH

243rd National Meeting (2012)

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