Beta sheets are common to many protein native states, relevant for a variety of key functions.  However, they also play a key role in protein misfolding, especially in amyloid fibrils.  Using data from recent millisecond all-atom simulation results from Folding@home (G. Bowman, V. Voelz, and V. S. Pande.  JACS 133  664-667 (2011)), I will present a new theory which connects these issues and suggests a new role for beta sheets in protein folding and misfolding.

Proteins and beta sheets: A perfect marriage or bad romance?

243rd National Meeting (2012)

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