We are engaged in the development of reliable and widely applicable ultrasensitive biosensing methodologies for the multiplexed in vitro detection of nucleic acid and protein biomarkers at extremely low (femtomolar) concentrations in microliter sample volumes.  In this talk we will highlight the application of SPR phase imaging methods to aptamer microarrays and the enzymatic capture of biomolecules with biofunctionalized nanoparticles coupled to surface enzymatic amplification chemistries for ultrasensitive biosensing. The ability to track DNA, RNA and proteins at femtomolar concentrations will facilitate the creation of better methods for early disease detection and strategies for post-treatment patient monitoring.

Novel combined methodologies for ultrasensitive biosensing: SPR phase imaging, enzymatic nanoparticles and aptamer microarrays

243rd National Meeting (2012)

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