Nanobiodevice is a piece of contrivance, equipment, machine, or component, which is created by the overlapping multidisciplinary activities associated with nanotechnology and biotechnology, intended for biological, medical, and clinical purposes.  During the past decade, nanobiodevice has progressively begun to focus on the establishment of main four fields of biomedical applications of nanotechnology, including 1) diagnostic devices, 2) molecular imaging, 3) regenerative medicine, and 4) drug delivery systems.  In this lecture, I will describe the development of nanobiodevices to analyze biomolecules and cells towards biomedical applications.[1-7]  I developed nanopillar device for the ultra fast separation of DNA and nanoball materials for the ultrafast separation of wide range of DNA fragments in single molecular level.  These devices are also applicable to fast and low invasive blood marker detection of cancer with fM detection sensitivity.  Additionally, I developed new synthetic method of quantum dots (QDs) based on the appropriate cluster confirmation by the ab initio molecular orbital calculation. QDs are applied to the development of nanobiodevice for single cancer cell diagnosis, single molecular epigenetic analysis, in vivo imaging for stem cell therapy and theranostic device for cancer diagnosis and therapy.References [1]      M. F. Serag, et al., ACSNano., 5, 493, (2011).[2]      H. Hatakeyama, et al., Biomaterials, 32, 4306, (2011).[3]      J. Wang, et al., Anal. Chem., 83, 3528 (2011).[4]      T. Yasui, et al., Anal. Chem., 83, 6635 (2011).[5]      T. Yasui, et al., ACS Nano, in press (2011).[6]      Y. Takasaki, et al., Anal. Chem., in press (2011).[7]      M.F. Serag, et al., ACS Nano, in press (2011).

Nanobiodevice based single molecule and single cell sensing for  cancer diagnosis and in vivo imaging of stem cell therapy

243rd National Meeting (2012)

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