Melanin is responsible for skin color and melanogenesis is mainly regulated by tyrosinase. Skin hypopigmenting is thought based on down-regulating melanin synthesis by inhibiting the activity of tyrosinase. Tyrosol and its glycoside, salidroside, were active components of Rhodiola rosea. In our previous study, we found that Rhodiola rosea exhibited melanogenesis inhibition. In this study, tyrosol and its glycoside, salidroside were examined for their effect on melanin synthesis. Tyrosol and salidroside inhibited a-MSH-induced MC1R expression. The results indicated that tyrosol and salidroside could suppress the expression of tyrosinase and TRP-1. Salidroside would inhibit the activity of tyrosinase in B16 cells. Furthermore, tyrosol below 4 mM and salidroside below 0.5 mM also showed no cytotoxity.   Key words: melanogenesis, tyrosol, salidroside, MC1R

Melanogenesis nhibition of tyrosol and its glycoside, salidroside on in B16F0 cells

243rd National Meeting (2012)

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