Encapsulation technology for drug delivery is widely applied to prevent undesirable degradations in the digestive system by the enzymatic attack and pH instability in the gastrointestinal tract. In this research, an ionic gelation method was developed using chitosan and phytic acid. Bovine serum albumin (BSA) is selected as a model drug. Optimization was based on response surface methodology, the ratio between chitosan and BSA, the concentration of phytic acid, pH, and the concentration of chitosan were selected as independent variables, and encapsulation efficiency and percentage drug release were chosen as dependent variables. The size distribution and the morphology of optimized microparticles were evaluated in this study.

Preparation and optimization of chitosan microcapsules using phytic acid for protein drug delivery

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.