We report on the stimulus-responsive Si-MPs with CD gatekeepers covalently connected onto the particle surface via disulfide unit and their glutathione (GSH)-induced controlled release characteristics of guest molecules from the pore. In particular, we also report a GSH-stimulated release of doxorubicin (DOX), an anticancer drug, from Si-MPs in the GSH-rich cancer cell, A549. The Si-MPs are composed of the surface CD gatekeepers, disulfide stalks as GSH-induced cleavable linker, and DOX or calcein as guests within the porous channels. In addition, for the release experiment in the cell line, the surface of Si-MPs was PEGylated for enhanced solubility in aqueous media. For in vitro experiment, DOX was loaded in the pore of Si-MPs, and its release from Si-MPs was investigated.

Glutathione-responsive mesoporous silica nanocontainers with cyclodextrin gatekeepers for drug delivery application

243rd National Meeting (2012)

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