A strand displacement-based system has been developed that substitutes inosine for guanosine in DNA sequences called �zippers�.  Each zipper sequence employs traditional adenosine-thymine bonding as well as non-traditional inosine-cytidine bonding.  These zippers can be introduced as an active element in larger DNA devices.  The first example is of zippers incorporated into single and double �spring� systems.  The springs incorporate in such a manner that allow them be repeatedly extended and contracted.  Multiple springs can be incorporated into larger 2D and 3D DNA structures, allowing them to change between conformations on demand. Such structures include a gating system involving a releasable DNA/Au nanoparticle plug across a hemolysin channel in a supported lipid membrane.  Zippers can also be put together in such a way as to deliver localized amounts of force on to any attached molecule or surface.  There are many applications that zippers can be used.

Zipper-based devices and future directions

243rd National Meeting (2012)

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