Herein, we present polymeric drug carrying micelles and nanoparticles capable of undergoing well defined and enzyme directed release of cargo. These systems aim to address the chief issue of drug-delivery systems, which is primarily the selective and specific targeting of diseased cells and avoidance of non-specific side-effects. Dye-labeled peptide substrates were directly polymerized generating enzymatically responsive materials capable of providing an alternative and improved approach for the localization and visualization of drug delivery processes mediated by cell-membrane proteases associated with metastatic cancer. These materials serve as molecular diagnostics for disease detection and drug release.

Dye-labeled and drug loaded enzyme-responsive polymeric materials

243rd National Meeting (2012)

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