Acyl-transfer reactions involving amides and weak nucleophiles are exceptionally rare. However, we have found a series of N-aryl amides capable of providing aryl ketones by Friedel-Crafts acylation (eq 1-2). When Br�nsted acid catalysts are used, the nitro-substituted aryl groups activate the acyl group towards nucleophilic attack. The results of these studies will be presented. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/239nm/uploads/16790_acs.jpg' alt='' />

Friedel-Crafts acylation with amides

243rd National Meeting (2012)

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