Gold nanoparticles (AuNPs) are being used for diagnostic and therapeutic purposes; however, their potential health risk(s) are still under investigation. Various reports have shown that nanobased materials can facilitate stem cell therapy for bone tissue engineering and wound healing.In this study we have investigated the effect of AuNPs on human adipose derived stromal cells (ADSc) and found that the uptake of the AuNPs is a function of time, their size and concentration as well as culture media used. Exposure to AuNPs affects the ADSc differentiation and results in the adipogenesis suppression by down regulation of adiponectin, known adipogenesis marker, and lipid accumulation inhibition.  ADSc fibronectin expression was also inhibited by AuNPs as well as cell migration and collagen contraction.Lastly, our data indicates that AuNPs damage to ADSc is not permanent and that cells recover as a function of lipid accumulation.

Effect of gold nanoparticles on adipose derived stromal cells

243rd National Meeting (2012)

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