We have developed that a modified oligodeoxynucleotide (ODN) containing 3-cyanovinylcarbazole nucleoside (CNVK) can be photoreversibly crosslinked with cytosine or thymine via UV irradiation at two different wavelengths, and perform the reversible DNA photocrosslinking via [2+2] cycloaddition between CNVK and cytosine or thymine on the irradiation condition of seconds. We have also developed photo-induced artificial DNA and RNA editing based on our ultrafast reversible DNA and RNA photocrosslinking.

Development about photochemical DNA and RNA crosslinking via 3-cyanovinylcarbazole

243rd National Meeting (2012)

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