Polysaccharides are widely used for the preparation of nanoparticles or nanocapsules, which are of strong interest for medical, pharmaceutical, food- and bio-technological applications.The main limitations of polysaccharide nanoparticles are on the one hand the hydrophilicity of most polysaccharides, which for example does not allow the entrapment of active hydrophobic substances into the particle core. On the other hand, hydrophobic cellulose ester nanoparticles lack of specific surface functionalities.Using nanoprecipitation technique, we have generated polysaccharide composite nanoparticles of different surface charge and functionality. These particles consist of a hydrophobic cellulose acetate core, and a variable functional hydrophilic polysaccharide surface. The nanoparticles were successfully loaded with hydrophobic substances, showed a very specific adsorption behavior, and were used for introducing strong antimicrobial properties to cellulosic supports.    The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n� 214653.

Tailored designed polysaccharide composite nanoparticles and possible applications

243rd National Meeting (2012)

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