We have prepared a novel erythrocyte membrane coated nanoparticle platform with tunable size and excellent stability. In this platform, biodegradable PLGA polymeric nanoparticles are covered in the phospholipid membrane bilayers derived directly from RBCs. Using an adapted mechanical extrusion method, we demonstrate the translocation of membrane lipids, surface proteins, and their functionalities from RBCs to the nanoparticles. The resulting particles have a sharp unimodal size distribution and uniform membrane coverage. In PBS, the particles remain stable for two weeks and upon injection in mice, the RBC membrane coating enables a long circulation half-life that's superior to PEG coating. The platform presents a unique and innovative approach in nanoparticle functionalization. It serves as a new model for the study of colloid-supported membrane bilayers and offers new opportunities in stealth nanoparticle drug delivery.

Red blood cell membrane coated polymeric nanoparticles

243rd National Meeting (2012)

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