The combination of our interest in the cyanobacteria-derived polyketides and the development of the ether transfer methodology has inspired us to explore new methodologies for the production of unique methyl substituted polyketide structural units. The extension of the ether-transfer methodology enabled the stereoselective formation of tertiary ethers and was applied to the synthesis of the C9-C19 fragment of Lyngbyaloside C. In addition, modification to ether transfer substrates and activating conditions were investigated in an effort to promote intramolecular 1,5-hydride transfer.

Novel access to methyl substituted polyketides structural units

243rd National Meeting (2012)

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