A silanol-directed, Pd-catalyzed synthesis of catechols from phenols via C-H oxygenation is disclosed. This method is highly regioselective and general, as it allows for oxygenation of not only electron-rich- and electron-neutral- but also electron-deficient phenols. The scope will be presented and detailed mechanism of this reaction will be discussed.

Pd-Catalyzed regioselective synthesis of catechols from phenols via traceless silanol-directed C–H oxygenation

243rd National Meeting (2012)

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