We have designed a 21-residue a-peptide that simultaneously recognizes two decadeoxyoligothymidine (dT10) tracts to form triplexes with a peptide-DNA strand ratio of 1:2.  The synthetic peptide sidechain-displays ten melamine rings, which provide a bifacial thymine-recognition interface along the length of the 21-residue peptide.  Recognition is selective for thymine over other nucleobases and drives the formation of ternary peptide*[dT10]2 complexes as well as heterodimeric peptide*[dT10C10T10] hairpin structures with triplex stems.  The use of this recognition strategy in different contexts will be described.

Structure-Inducing molecular recognition of single-stranded oligonucleotides with synthetic nucleobase-pairing

243rd National Meeting (2012)

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