In the real world we face a complex mixture of endocrine (EDC) agonistic and anti-agonistic stressors such as anabolic steroids, hormones, which exert their effects through a wide range of nuclear hormone receptors. Monitoring the quality of the aquatic environment by analyzing a (limited) defined set of compounds can impossibly be translated into the biological effects of the mixture. Current global emphasis in of EDC research lies on the measurement of estrogenic and androgenic compounds. In this study, a panel of CALUX� bioassays testing for estrogen (ERa CALUX�), androgen (AR CALUX�), progesterone (PR CALUX�), glucocorticoid (GR CALUX�) and thyroid (TR� CALUX�) receptor (agonistic and antagonistic) activity has been applied to all kinds of water extracts; such as STP effluents (industrial and municipal), surface water and drinking water. The results show that the CALUX� panel can successfully be applied to complex samples such as waste water and surface water extracts.

Multiple biodectectors for bioassay detected chemical analysis for water

243rd National Meeting (2012)

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