Public concern over health issues relating to endocrine disruptors and pharmaceuticals in the water supply are mounting, particularly as related to the unknown long-term effects on infants and children.  Sensitive bioassays that can assess the functional activity of an unknown compound for potential endocrine disruption would benefit routine testing of water supplies and allow establishment of limits that ensure public safety. Life Technologies has developed a broad portfolio of cellular bioassays that can be used to detect biological activity of key endocrine signaling pathways.  These assays are simple, robust, reproducible and can be used in a high-throughput, automated systems.  In addition, many have been applied to environmental toxicity testing and were selected for the TOX21 program initiated by National Toxicology Program (NTP), NIH and EPA.  We will review the underlying technology for the bioassays and highlight their use for endocrine disruption assessment.

High-throughput compatible bioassays for detecting endocrine disrupting chemicals in water supplies

243rd National Meeting (2012)

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