Polymer micelles prepared from amphiphilic block copolymers are of considerable interest in the biomedical field as nanometer-scale drug carriers. Such polymer micelles have a hydrophobic inner core and hydrophilic outer shell architecture, and show long-term circulation in the bloodstream after intravenous administration by preventing rapid renal excretion and immobilization by the reticuloendothelial system. However, there are still problems of instability of such polymeric micelles in body fluids after intravenous injection, due to dissociation under diluted conditions below the critical micelle concentration and interaction with blood components. We developed highly stable biodegradable polymeric micelles by coating positively charged PLys-b-PLLA micelles with negatively charged hyaluronic acid (HA). In this paper, to evaluate the fundamental properties of PLys-b-PLLA micelles coated with HA (HA-coated micelles) as cell-specific drug carriers, their drug loading and release behavior, cytotoxicity, uptake of HA-coated micelles into liver sinusoidal endothelial cells were investigated.

Polyion complex coated biodegradable block copolymer micelles as highly stable cell-specific drug carriers

243rd National Meeting (2012)

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