A smart approach has been developed to form nanoassemblies with tunable shell's functions by simply mixing three different block copolymers with a common temperature responsive segment at room temperature. Regardless of the block copolymer types, acrylamide-type, ether-type, and methacrylate-type, the selected block copolymers successfully formed a stable core-shell assembly with the collapsed common segments forming the inner core. The characteristic property of the assembly could be easily tuned by changing the mixing ratio of three block copolymers. This system is highly promising as smart nano-carriers for encapsulation, targeting, and triggered release of drug under control through a combination of the mixed block copolymers.

Multifunctional nano-assemblies by simple mixing of block copolymers

243rd National Meeting (2012)

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