Amphiphilic block copolymer systems are of increasing interest due to their ability to form a variety of aggregate structures that have great potential in targeted drug delivery and diagnostic systems. Predicting the morphology of a given aggregate formed by an amphiphilic block copolymer can be problematic as its formation depends on many different variables. In our study, ring opening metathesis polymerization (ROMP) was used to build a library of block copolymers with varying molecular weight, functional group identity, density, and functional group ratios. This library was subjected to dialysis and the resulting aggregates analyzed via dynamic light scattering, static light scattering, fluorescence spectroscopy, TEM, and Cryo-TEM reconstructions, revealing trends between polymer characteristics and aggregate morphology at high resolution.

Morphologies of brush copolymer amphiphile micelles including complex assemblies of peptide-polymer amphiphiles

243rd National Meeting (2012)

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