For the therapeutic management of chronic diseases, the systems medicine approach shows great promise. Starting from such therapeutic indications that are relevant for complex, multifactorial chronic diseases (e.g., diabetes, asthma, cancer), we examine the relationship between drugs, targets, current indications and counter-indications, as well as serious adverse reactions. The analysis is aided by the use of controlled vocabularies such as those available in MedDRA and ICD-10, and benefits from manual curation. Practical aspects such as single vs. multiple (chronic) dosing, as well as temporal patterns (evolution of disease states) will be considered. Such aspects are likely to pave the way towards a systems medicine approach and improve our understanding of the therapeutic control of chronic diseases.

Integrating targets, drugs and clinical outcomes into systems medicine

243rd National Meeting (2012)

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