Stimuli-responsive polymers play a central role in the development of particle-based carriers for biomedical applications and biochemical reactions. This presentation will focus on polymer capsules assembled through the deposition of engineered polymers with tailored functionalities. Emphasis will be placed on particles prepared via sequential polymer assembly. New strategies to generate responsive particles through a single polymer adsorption step will also be presented. Utilization of these nanostructured particles for the encapsulation, protection and release of oligonucleotides and peptides to stimulate immune responses will be highlighted.  The preparation of hydrogel capsules that possess size and charge exclusion properties to allow for selective permeability of reaction components and facile control over capsule architecture, affording the continuous synthesis of nucleic acids and the assembly of liposome/polymer composites with a subcompartmentalized structure reminiscent of cells, will also be discussed.

Stimuli-responsive, engineered particles designed to interface with biology

243rd National Meeting (2012)

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