Stimulus-responsive macromolecular structures are of tremendous importance for next-generation tools for biotechnology, such as contrast-enhanced deep-tissue imaging with high sensitivity and low background. Here, we present our research on creating stimulus-responsive ultrasound-active colloids through careful design of surface chemistry.  First, we created microbubbles that change their ultrasound contrast properties in response to the addition of specific biomolecules.  These were found to produce a strong signal only in the presence of thrombin, a biomarker for deep venous thrombosis.  Second, we created low-contrast superheated nanoemulsions that change their ability to become high-contrast microbubbles in response to chemically-induced changes in their surface properties.  Both examples showcase a method for obtaining site-specific or biomarker-specific contrast enhancement for deep tissue imaging using commercially available equipment.  Current studies include both proof-of-concept ex vivo and biological validation studies.

Stimulus-responsive microbubbles and nanoemulsions as “smart” contrast-enhanced ultrasound imaging

243rd National Meeting (2012)

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