Mono-, di-, and triglycerides are important materials for drug delivery applications especially for the preparation of drug-loaded nanoparticles.1 Thus, monoglycerides are frequently used in formulations of solid-lipid nanoparticles (SLNs). SLNs are prepared from nanoemulsions of a solid lipid, i.e. the addition of emulsifiers, such as Pluronic or Tween type polymers, is necessary in order to stabilize the SLNs in water. Such nanoparticles are usually of spherical shape but also polygonal shapes have been reported for particles formed by the monoglyceride of oleic acid (cubosomes). Here a new approach based on polymeric glycerides is proposed. Glycerol and divinyladipate can be employed for the formation of linear polyesters when the polycondensation is carried out in the presence of the enzyme CAL-B from Candida antartica. Then the remaining OH groups are esterified to different degrees by fatty acids.

Fatty acid modified poly(glycerol adipate)- polymeric analogues of glycerides

243rd National Meeting (2012)

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