Polymers such as polyvinylpyrrolidone (PVP) have been used to prepare hydrogels for wound dressing applications. For enhanced healing, release of therapeutics from these hydrogels has been studied, but with limited control over drug release profiles. To overcome the limitations of current systems, two salicylate-based poly(anhydride-esters) (PAEs) of differing hydrophilicity (aliphatic vs. heteroatom �linkers�) were prepared and blended with PVP at various ratios. To elucidate the effect of linker structure on physical properties of the blends, they were cast into films and hydrated to form physical hydrogels. In general, the blends with the PAE aliphatic linker had higher swelling values than their counterparts. Porosity was evaluated via scanning electron microscopy, demonstrating <10 �m pore sizes for the aliphatic-based 7:3 PVP/PAE ratio. The drug release profiles of the blends were studied in vitro, demonstrating the chemically incorporated SA was released from the hydrogels over 11 days for the aliphatic-based PAEs.

Biodegradable salicylate-based poly(anhydride-ester)/polyvinylpyrrolidone blends as hydrogel drug delivery systems

243rd National Meeting (2012)

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