Ultra-thin polymer films (polymer nanosheets) have unique property; nanosheets provide sufficient adhesiveness, flexibility and robustness owing to their huge aspect ratio. Therefore, nanosheets composed of biocompatible polymer act as suitable wound dressings. Moreover, nanosheets have highly transparency. This high transparency facilitates observation of the burn-wound healing process. We recently developed an antimicrobial agent (tetracycline, TC)-loaded nanosheet composed of polysaccharides (referred as 'TC-nanosheet') and demonstrated its therapeutic efficacy with a murine cecal puncture model. Herein, we investigate the therapeutic efficacy of the TC-nanosheet against burn-wound infection in a murine model. An in vivo treatment using the TC-nanosheet significantly improved burn-wound infection with P. aeruginosa in mice, thereby increasing mouse survival. We conclude that the TC-nanosheet can act as an effective treatment for full thickness burn-wound infection.

Therapeutic effects of tetracycline-loaded nanosheet for a deep burn-wound infection model

243rd National Meeting (2012)

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