The transfer of chirality from a guest molecule to an achiral host is the subject of noteworthy interest. The ability to induce supramolecular chirality as well as to control the twist-sense and the degree of helicity plays a vital role in the frontier of biomolecular recognition, material science and information storage. Although helical-induction of single-stranded helices has been performed in the past, for example, by covalently adhering enantiopure chiral additives to foldable polymers1,2, the induction of double-stranded helices is rare.  The double-stranded helical structures are frequently found in nature and are closely related to the physiological functions of biomolecules, such as nucleic acids (DNA, RNA, even PNA) and proteins. This work presents molecular modeling investigations that aim to develop a novel tool for helical-sense programming of double-stranded architectures. These investigations are based on Monte Carlo and Stochastic Dynamics searches. 1. Yashima, E.; Katsuhiro, M. Macromolecules (Review). 2008  , 41, 3�12.2. Sanji, T.; Takase, K.; Sakuria, H. J. Am. Chem. Soc. 2001  , 123, 12690�12691.

Helical molecular programming via supramolecular complexation of bis-porphyrins

243rd National Meeting (2012)

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