The environmental significance of chirality in organophosphorus pesticides (OPs) is currently of great interest. All OPs used in agriculture are applied in their racemic forms, but the enantiomers usually differ in their biological activities and degradation processes. Therefore, it is of importance to isolate them and define their chirality. Knowledge of the Absolute Configuration (AC) is essential in furthering their utility as pesticides with minimal adverse consequences on health and overall ecosystem wellbeing.  Our goals are to isolate the enantiomers of selected OPs and employ sinergy of three chiroptical methods to reliably estalish the AC. Chiroptical elucidations will involve complementary experimental and quantum mechanical studies, as this combined approach serves as reliable means for establishing the AC. In addition, the studies will provide an assessment of: a) which chiroptical method gives the most dependable and cost-effective AC assignment; b) which cases favor the use of more than one method.

Absolute configuration determination of organophosphorus pesticides

243rd National Meeting (2012)

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