T cells are a class of immune cells that can eliminate cancer cells. Various immunotherapy approaches are being developed that involve manipulating T cells to make them attack cancer, including the genetic modification of T cells to express receptors that recognize tumor cells. In this preliminary analysis we are evaluating materials collected from an animal study to determine the ability of T cells, modified with a receptor that has been modified to be more potent, to target ovarian cancer. Goal is to: Evaluate the ability to use quantitative real time PCR to obtain information about the trafficking to tumors and activity of T cells   that have been genetically engineered to target ovarian cancer.Critical information will be provided about the feasibility to perform this type of analysis in both animal models and clinical studies and it will also provide comparative information about different targeting agents used to engineer the T cells.

Q-RT- PCR analysis of the immunological milieu in tumors post t-cells immunotherapy: Applications in immunology

243rd National Meeting (2012)

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