The investigation of the hydrolysis of 2-chloro-1-methyl-4-pyridone and 6-chloro-1-methyl-2-pyridone will provide insight on the mechanism of hydrolysis of 6-cyanouridine 5'-monophosphate (6-cyano-UMP) to B-D-ribofuranosylbarbiturate 5'-monophosphate (BMP) catalyzed by the enzyme orotodine 5'monophosphate decarboxylase (ODCase).  ODCase plays a key role in the de novo synthesis of puridine nucleotides, and the mechanism on which it acts remains unknown. Hydrolysis of the synthesized pyridone structures will reveal how the polarity of the substrate structures affect their reactivity.  Our hypothesis is that ODCase catalyze the reaction by polarizing the substrate.

Polarity studies of the orotidone 5'-monophosphate decarboxylase mechanism

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.