Considerable attentions have been given to Single Walled Carbon Nanotube (SWCNT) for various biomedical applications including bone and neural tissue engineering due to its extraordinary mechanical and electrical properties. For this, we have prepared certain complexes of SWCNT grafted with different molecular weight polysaccharides, named as SWCNT-Glucosamine, SWCNT-Chitooligosaccharide (<1KDa), CNT-Chitooligosaccharide (1-3 KDa), SWCNT-Chitosan (310 KDa) and SWCNT-Chitosan (510 KDa) and subjected to bone tissue engineering application in vitro with mesenchymal stem cells. The physicochemical characteristic results revealed the existence of covalent bond between SWCNT and their respective polysaccharides. SWCNT-low molecular weight polysacchrides have been used for the cell culture experiment due to its highly soluble nature. No cytotoxic effect, higher alkaline phosphatase activity and enhanced mineralization have been observed in SWCNT-low molecular weight polysacchrides compared to low molecular weight polysacchrides only. We propose that SWCNT-Polysaccharide derivatives are promising biomaterials for bone tissue engineering.

Stimulation of minerals by carbon nanotube grafted natural polymers in mouse mesenchymal stem cell for bone tissue engineering

243rd National Meeting (2012)

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