Inhibition of cholesteryl ester transfer protein (CETP) has provided a compelling target for the treatment of cardiovascular diseases given to its promising effects on plasma lipoprotein levels. Events surrounding the discovery, development and discontinuation of torcetrapib will be described.

Fluorophilic pharmacophore for cholesteryl ester transfer protein inhibition: Discovery and demise of torcetrapib

243rd National Meeting (2012)

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