As synthetic chemists, we increasingly seek methods, techniques and strategies for building complexity into molecular systems. This is especially true and challenging in the context of nanomaterials. Some of the challenges in preparing complex materials include characterization, the ability to track materials once self-assembled and observing their behavior in vitro. With this in mind, ring-opening metathesis polymerization (ROMP) provides a tool for the generation of well-defined polymers of low polydispersity and highly functionalized architectures. In order to incorporate visualizable labels into amphiphilic ROMP polymers, a variety of monomeric units and termination agents have been synthesized, polymerized, and subsequently self-assembled into micellar architectures. The newly formed dye-labeled micellar materials allow for characterization of particle stability and 3D architecture by utilizing fluorescent spectroscopy intensity and lifetime methods.

Dye-labeled polymeric micellar nanoparticles

243rd National Meeting (2012)

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