In this project star-shaped popypeptides of different molecular weights were synthesized using amino-terminated 8-arm polypropylen imine (PPI) dendrimer as initiator for the ring opening polymerization of ?-propargyl L-glutamate N-carboxyanhydride (NCA). Solubility problems were overcome by the use of DMSO for the polymerization. IR and NMR spectroscopy confirm the polypeptide structure. The increase in the number of repeating units resulted in different polypeptide conformations as shown by FTIR amide band analysis.  The alkyne functional polypeptide star polymers will further be employed in orthogonal glycosylation by click reaction with azide functional galactose to obtain three-dimensional micelle-like structures, which can be used for potential drug delivery or imaging purposes.

Synthesis of glycopolypeptide star polymers using PPI dendrimer as initiators

243rd National Meeting (2012)

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