Random copolymers based on poly(N-ethyl glycine) and poly(N-butyl glycine) [i.e., c-P(NEG-r-NBG)] have been synthesized by NHC-mediated copolymerization of the corresponding N-substituted N-carboxyanydride monomers. The copolymers are thermally responsive and exhibit lower critical solution temperature (LCST) or cloud point (Tc) with minimal hysteresis in aqueous solution. The Tc can be readily tuned between 25 to 60 �C by controlling the copolypeptoid composition, architecture, and end-group structure. The copolypeptoids are mostly non-cytotoxic, comparable to poly(ethylene glycol) (PEG), a benchmark biocompatible polymer, enhancing their potential uses in biotechnology and biomedicine.

Comparative study of linear and cyclic polypeptoids' thermo-responsive property

243rd National Meeting (2012)

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