In this contribution, selected examples of the properties and use of POx as potential polymer therapeutics will be presented. This will include the use of amphiphilic POx copolymers as high-capacity delivery systems for hydrophobic drugs, especially paclitaxel as a potent anti-cancer drug, POx for the formulation of fullerenes as antioxidants for the treatment of brain-related diseases associated with increased levels of superoxide, POx copolymer-enzyme conjugates as a new platform for enhanced cellular delivery and POx-stabilized virus-like particles (POx-VLPs) as a new drug-delivery platform. In this context the relevant properties of various POx homo- and copolymers such as biodistribution and excretion (mice), cytotoxicity and cell uptake as a function of the structure and amphiphilic contrast of POx will be discussed.

Poly(2-oxazoline)s as polymer therapeutics

243rd National Meeting (2012)

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