Chronic inflammation has been recognized for nearly 200 years to contribute to the development of cancers in multiple organ sites. The chemical events that contribute to this linkage are complex and include induction of DNA damage and mutation, release of growth factors that enhance wound-healing and cell proliferation, and production of bioactive lipids that stimulate angiogenesis. Understanding the chemistry responsible for this biology provides strategies for detection, prevention and treatment of inflammation associated cancers. The focal points for this lecture will be the chemistry of inflammation-related DNA damage, the mutagenicity of the damage products, the enzymology of lipid mediator generation, and the synthesis and in vivo validation of agents for the detection and prevention of cancer.

Award Address  (George   & Christine Sosnovsky Award for Cancer Research sponsored by the George   and Christine Sosnovsky Endowment Fund). Role of inflammation in the cause, detection, and treatment of cancer

243rd National Meeting (2012)

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