With the aid of a planar-chiral 4-dimethylaminopyridine (DMAP) derivative and an alcohol racemization catalyst, nonenzymatic dynamic kinetic resolution of secondary alcohols can be achieved through enantioselective acylation. The reaction proceeds in high yield and high enantiomeric excess with a variety of alcohols. Studies into the development and the scope of this methodology will be discussed.

Nonenzymatic dynamic kinetic resolution of alcohols catalyzed by planar-chiral DMAP derivatives

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.