The use of metal catalysts, in order to hydrolyse terminal alkynes, to yield methyl-ketones presents an interesting challenge; current methods include the use of mercury compounds with intrinsic unfavourable health effects and so other routes would be desirable. Some Group (III) triflates show activity for the hydration of benzylic alkynes and concurrent work is investigating analogous modes of nitrile activation for the production of pyridines via a Diels-Alder type reaction.

Metal catalysis for the application of the hydration of alkynes and the Diels-Alder addition to nitriles

243rd National Meeting (2012)

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