Although CO2 is a readily available and inexpensive C1 source, it is quite challenging to access alkyl carboxylic acids without employing organometallic reagents that limit the substrate scope of the reaction.  Very few examples of the direct hydrocarboxylation of olefins are known and these approaches often utilize either precious metal catalysts or pyrophoric organometallic reagents.  This presentation will discuss our synthetic and mechanistic efforts in the development of Cu-catalyzed tandem reactions for the conversion of olefins and related substrates into alkyl carboxylic acids using CO2 as the C1 source.  The extension of these mild, inexpensive and functional-group tolerant methods to other C-C bond-forming reactions will also be described.

New methods for the addition of small, gaseous molecules to unsaturated hydrocarbons

243rd National Meeting (2012)

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