Bacterial cellulose (BC) consists of ribbon-shaped nano-fibers in web-like structures. Poly (N-isopropylacrylamide- co- butylmethacrylate) (PNB) nanogel dispersion exhibited reversible thermosensitive sol-gel phase behaviors and it could be used as a new material for interventional therapy. In this paper, BC whiskers were nanosized and then utilized to prepare BC whisker/PNB nanogel complex, which could enhance the bloodvessel-embolization property of PNB nanogel.The morphology and average size of the nanogel complex were characterized by transmission electron microscope (TEM) and dynamic light scattering (DLS). The vial inverting with visual method and differential scanning caborimetry (DSC) ware utilized to study the thermosensitive behaviors of concentrated BC whisker/PNB nanogel complex Iohexol dispersion.The kinetics of the thermosensitive volume phase transition of BC whisker/PNB nanogel complex was evaluated by rheological tests. The concentrated dispersion showed good shear thinning behavior, which plays a key role on the interventional therapy for hepatocellular carcinoma.

BC whisker/P (NIPAM-co-BMA) nanogel complex for interventional therapy of hepatocellular carcinoma

243rd National Meeting (2012)

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