Since the introduction of the variational implicit solvent model (VISM) in Andy McCammon's group back in 2006, the numerical evaluation and the applicability of this continuum solvent model to the hydration of complex molecules has been further developed and tested. In this talk I briefly review what has been accomplished so far and what we may expect to see in the future.

More than five years of VISM: Where do we stand?

243rd National Meeting (2012)

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