Biological responses are strongly related to the adsorbed protein layer on a materials surface. To understand protein adsorption at a materials surface, it is important to clarify the factors for surface properties dominant to protein adsorption. The perspective of this study is to elucidate the protein adsorption behavior at the biomaterials surface from a viewpoint of a water structure surrounding the material surface. In this study, the properties of water molecules enclosed among the micro-beads with the polymer brush layers were analyzed with 1H-NMR measurement. The nano-newton ordered adsorption forces of protein against the polymer brush layers were analyzed with atomic force microscopy. The zwitterionic polymer brush layers, which had little adsorption force of protein, made a thick hydrated layer with high mobility around them. We will quantitatively discuss the relationship between the water structure and protein adsorption behavior at the biocompatible polymer brush layers.

Evaluation of protein adsorption at polymer brush surfaces based on the water structure surrounding the surface

243rd National Meeting (2012)

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