Positron emission tomography (PET) is a widely used technique that generates 3-D images of the body functions via a positron-emitting radionuclide (tracer). We report synthesizing an azide-bearing multi-functional tracer using a coupled cross-bridged tetraazamacrocycle which is a chelator for 64Cu, a positron source. Using click chemistry, two peptides could be coupled to each chelate using one clickable alkynyl amino acid. Such a functionalized cross-bridge tetraazamacrocycle with two identical azide-bearing side arms provides several advantages with respect to applications. This tracer would increase the avidity of the agent and potentially allow attachment to more than one clickable amino acid.

Multifunctional PET tracer based on a pendant-armed cross-bridged  tetraazamacrocycle scaffold

243rd National Meeting (2012)

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