We are attempting to develop the novel phenolic synthetic antioxidants aimed at retarding the effects of free radicals and oxidants. The phenolic compounds were synthesized by Friedel-Crafts alkylation of isoeugenol, phenol, pyrocatechol and resorcinol and their structures were determined by spectroscopic methods. Antioxidant and radical scavenging activities of synthesized compounds were determined by using various in vitro assays such as 1,1-diphenyl-2-picrylhydrazyl free radicals (DPPH.), 2,2-azino-bis(3-ethylbenzothiazoline-6- sulfonic acid) radicals (ABTS?+), and superoxide anion radicals (O2-) scavenging, ferric reducing antioxidant power (FRAP) and total antioxidant activity by ferric thiocyanate. The antioxidant activities of compounds were compared with standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and trolox as positive controls.   The compounds 3   and 4,   containing a catechol moiety, showed the highest activity in all assays. These results suggest that these new phenolic compounds are promising candidates to be used as alternative antioxidants to BHA and BHT.

Synthesis of new phenol compounds from isoeugenol: Investigation of antioxidant properties

243rd National Meeting (2012)

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