The pyridobenzimidazoles N2-phenylpyridine-2,3-diamine  were prepared from corresponding nitro compounds by tin chloride di-hydrate reduction and microwave irradiation under solvent free conditions. Furthermore, the starting nitro compounds were prepared from 2-chloro-3-nitropyridine and suitably substituted aniline under MW conditions. A new synthetic method was developed that provides ready access to a novel pyridobenzimidazoles derivates. In addition, a synthetic route for the preparation of amines under solvent free conditions was demonstrated. Lastly, detailed biological activity studies (antibacterial, fungal, cancer and neuroprotective kinase inhibitor activity) of these important compounds are being carried out and preliminary results indicate that many of these compounds exhibit excellent neuroprotecting properties

Synthesis of biologically important novel pyridobenzimidazoles attached to indole or benzothiophene structures

243rd National Meeting (2012)

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