Synthetic methodology leading to production of substituted urazoles is currently quite limited. As a prelude to the investigation of this heterocycle as a scaffold for drug design, we have investigated the synthesis of urazoles, particularly including substituted and bicyclic urazoles.  We have also obtained the crystal structures of a number of functional urazoles, including strained urazoles which show significant pyrimidalization of the amide nitrogens.

New synthetic methodology for the preparation of substituted urazoles

243rd National Meeting (2012)

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