Indole derivatives are among the most important scaffolds in many natural products and synthetic drugs.  Due to their biological significance, a variety of synthetic methods have been developed. However, all of the existing methods have shortcomings towards certain substitution patterns on the heterocyclic ring.  Herein we report a novel and practical approach towards the synthesis of indole derivatives from readily available starting materials. This methodology is quite versatile and allows the synthesis of a large variety of highly substituted indoles and related heterocyclic systems that contain substituents that are difficult to introduce. A number of examples of this chemistry will be presented.

Novel and practical method for the synthesis of indoles and other heterocycles

243rd National Meeting (2012)

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